Naomi R. Latorraca

Design principles of a membrane-spanning ubiquitin ligase

The paper describes the structure and function of a membrane-spanning E3 ubiquitin ligase complex, revealing its role in developmental processes and linking mutations to human birth defects.

Assembly and lipid-gating of LRRC8A:D volume-regulated anion channels

This study determines the structure of LRRC8A:D VRACs using cryo-EM, revealing lipid-gating and subunit-specific structural features.

Domain coupling in activation of a family C GPCR

This study identifies a pre-active intermediate in GPCR activation and shows how dimer interactions influence signaling efficacy and functional diversity.

A non-canonical mechanism of GPCR activation

This study identifies a non-canonical mechanism of GPCR activation where agonists directly rearrange an intracellular loop to regulate signaling, with implications for drug design.

Structural and Functional Characterization of G Protein-Coupled Receptors with Deep Mutational Scanning

This study uses deep mutational scanning to analyze GPCR variants, identifying key residues for signaling and function across multiple GPCR classes.