Macropinocytosis of amyloid precursor protein requires the adaptor protein Fe65 and the recruitment and activity of Arf6 and the RhoGTPases Rac1, Cdc42 and RhoA.
Jordan M Krupa, Abdul M. Naqvi, Manoj Reddy Medapati, Adrianna R Tsang, Claudia Seah, Stephen Pasternak
The paper demonstrates that Fe65 links APP to Arf6 and RhoGTPases to regulate macropinocytosis, which is critical for Aβ production in Alzheimer's disease.
bioRxiv · Mar 2, 2025 · PreprintNeuroscience