Author
Western University
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
3 papers
Recent·Most cited
Jordan M Krupa, Abdul M. Naqvi, Manoj Reddy Medapati…·Stephen Pasternak
The paper demonstrates that Fe65 links APP to Arf6 and RhoGTPases to regulate macropinocytosis, which is critical for Aβ production in Alzheimer's disease.
Jordan M Krupa, Manoj Reddy Medapati, Adrianna R Tsang…·Stephen Pasternak
This study shows that Arf6 and RhoGTPases Rac1, Cdc42, and RhoA are required for macropinocytosis of Aβ42 oligomers and tau fibrils in neurons, suggesting new targets to prevent their transfer in Alzheimer's disease.
Adrianna R Tsang, Manoj Reddy Medapati, Claudia Seah…·Stephen Pasternak
This study shows that lysosomal exocytosis releases amyloid beta from hiPSC-derived neurons, suggesting it as a therapeutic target for Alzheimer's disease.