Author

Manoj Reddy Medapati

Western UniversityORCID 0000-0002-6342-5546Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 1 Assay:proteomics· 1 Organism:rat· 1 Approach:statistical model· 1

Frequent Co-Authors

Stephen PasternakiD· 4 shared Adrianna R Tsang· 3 shared Claudia SeahiD· 3 shared Jordan M KrupaiD· 3 shared Abdul M. Naqvi· 1 shared Austyn D. RoseboroughiD· 1 shared Brian Leonard AllmaniD· 1 shared Sarah J. Myers· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

9 top collaborators · 20 mutual co-author links

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4 shared papersNeuroscience

Stephen PasternakORCID

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4 papers

Recent·Most cited

Increased circulating TREM2+ microglia extracellular vesicles in aged APP/PS1 Alzheimer's disease rats

Sarah J. Myers, Manoj Reddy Medapati, Brian Leonard Allman, Stephen Pasternak, Shawn Narain Whitehead, Austyn D. Roseborough

This study finds increased circulating TREM2+ microglia extracellular vesicles in aged APP/PS1 rats linked to cognitive impairment.

Brain Behavior & Immunity - Health · May 14, 2026Peer-reviewedNeuroscience

Macropinocytosis of amyloid precursor protein requires the adaptor protein Fe65 and the recruitment and activity of Arf6 and the RhoGTPases Rac1, Cdc42 and RhoA.

Jordan M Krupa, Abdul M. Naqvi, Manoj Reddy Medapati, Adrianna R Tsang, Claudia Seah, Stephen Pasternak

The paper demonstrates that Fe65 links APP to Arf6 and RhoGTPases to regulate macropinocytosis, which is critical for Aβ production in Alzheimer's disease.

bioRxiv · Mar 2, 2025 · PreprintNeuroscience

Macropinocytosis of aggregated amyloid-beta and tau requires Arf6 and the RhoGTPases Rac1, Cdc42 and RhoA.

Jordan M Krupa, Manoj Reddy Medapati, Adrianna R Tsang, Claudia Seah, Stephen Pasternak

This study shows that Arf6 and RhoGTPases Rac1, Cdc42, and RhoA are required for macropinocytosis of Aβ42 oligomers and tau fibrils in neurons, suggesting new targets to prevent their transfer in Alzheimer's disease.

bioRxiv · Mar 2, 2025 · PreprintNeuroscience

Amyloid beta is released by lysosomal exocytosis from hiPSC-derived neurons

Adrianna R Tsang, Manoj Reddy Medapati, Claudia Seah, Jordan M Krupa, Stephen Pasternak

This study shows that lysosomal exocytosis releases amyloid beta from hiPSC-derived neurons, suggesting it as a therapeutic target for Alzheimer's disease.

bioRxiv · Mar 1, 2025 · PreprintNeuroscience