An aneuploidy epistasis map reveals metabolic vulnerabilities associated with supernumerary chromosomes in cancer
Rayna Y. Magesh, Arshia N. Kaur, Faith N. Keller, Abdulrazak Frederick, Tenzin Tseyang, John D. Haley, Alejandra María Rivera Nieves, Anthony C. T. Liang, David A. Guertin, Jessica B. Spinelli, Stephen Joseph Elledge, Emma V. Watson
This study identifies metabolic vulnerabilities in aneuploid cancer cells through CRISPR screens and multi-omic analysis, revealing reliance on pyrimidine biosynthesis and sensitivity to DNA-damaging drugs.
bioRxiv · Sep 30, 2024 · PreprintCancer Biology