John D. Haley

Seipin mediates Perilipin-1 recruitment to lipid droplets to preserve human adipocyte identity

This study shows seipin is essential for recruiting Perilipin-1 to lipid droplets in human adipocytes, maintaining adipocyte identity and preventing de-differentiation.

UCP1 Mitigates Hepatic Steatosis and Fibrosis Independent of Cold Exposure

This study shows diet-induced thermogenesis reduces adiposity and protects against liver disease in male mice, with UCP1 playing a key role in BAT and non-adipocyte cells.

Functional Specialization of S-Adenosylmethionine Synthases Links Phosphatidylcholine to Mitochondrial Function and Stress Survival

The paper investigates the functional specialization of SAM synthases in C. elegans, showing that SAMS-1 affects mitochondrial function and stress survival through phosphatidylcholine, while SAMS-4 is critical for methylation reactions.

An aneuploidy epistasis map reveals metabolic vulnerabilities associated with supernumerary chromosomes in cancer

This study identifies metabolic vulnerabilities in aneuploid cancer cells through CRISPR screens and multi-omic analysis, revealing reliance on pyrimidine biosynthesis and sensitivity to DNA-damaging drugs.