Jessica B. Spinelli

The paper synthesizes and purifies rhodoquinone standards for absolute quantification in mammalian tissues and ETC studies.

This study uses GENEVA to analyze drug response variations in cancer cells, revealing mitochondrial activation's role in KRAS inhibition and EMT as a resistance mechanism.

This study identifies PTHrP as a driver of pancreatic cancer cachexia by suppressing adipose de novo lipogenesis, showing that blocking PTHrP-PTH1R signaling reduces wasting in mouse models.

The paper investigates the functional specialization of SAM synthases in C. elegans, showing that SAMS-1 affects mitochondrial function and stress survival through phosphatidylcholine, while SAMS-4 is critical for methylation reactions.

This study identifies Comamonas aquatica as a neuroprotective bacterium that prevents axon degeneration by providing Vitamin B12 to reduce homocysteine toxicity in C. elegans.

This study identifies metabolic vulnerabilities in aneuploid cancer cells through CRISPR screens and multi-omic analysis, revealing reliance on pyrimidine biosynthesis and sensitivity to DNA-damaging drugs.

This study identifies sex-specific metabolic reprogramming in obesity by analyzing phosphorylation sites on metabolic enzymes and their functional impact.

This study identifies MPST as the direct target of EGT, showing it enhances mitochondrial respiration and exercise performance in mice.