Multiomics Integration Reveals a Metabolic Myopathy in Cardiometabolic HFpEF
Timothy Daniel Allerton, Daniel A. Arabie, Kade Malone, Abhishek Pandit, Mahmoud H. Elbatreek, Zhen Li, Robert C. Noland, Jake E. Doiron, Mike Kinter, Brooke L. Loveland, Pravalika Javvadi, Kirti Agrawal, Manas Ranjan Gartia, Praveen Guttula, Traci T. Goodchild, , David J. Lefer
This study identifies a metabolic myopathy in HFpEF through multiomics analysis of skeletal muscle, revealing mitochondrial dysfunction and altered amino acid metabolism.
bioRxiv · Dec 18, 2025 · PreprintPhysiology