Michael T Kinter

This study shows that pathogenic ATAD3A mutations disrupt the RagC/D-TFEB axis, leading to lysosomal dysfunction and neurodevelopmental defects.

This paper shows that loss of PFKFB2 in cardiac cells leads to electrophysiological instability, including prolonged repolarization and ventricular tachyarrhythmia, linking glycolytic regulation to heart function.

This study shows that hepatocyte MLKL promotes obesity-driven MASLD-HCC through mitochondrial dysfunction and MFN2 suppression, independent of necroptosis.

This study identifies the extra-terminal domain as essential for BET protein function in transcription and chromatin occupancy.

This study shows that MLKL in hepatocytes promotes liver aging by inducing senescence and mitochondrial dysfunction without causing necroptosis.

This study identifies a metabolic myopathy in HFpEF through multiomics analysis of skeletal muscle, revealing mitochondrial dysfunction and altered amino acid metabolism.

This study shows that maternal exercise during lactation improves milk fatty acid composition and enhances offspring energy expenditure in obese dams.

This study shows that early-life exposure to high omega-6 fatty acids impairs adipocyte mitochondrial oxidation by suppressing NR2F2, which can be reversed by reactivating NR2F2 in stem-like cells.

This study identifies KIF5B as a key component of the force-generating machinery for meiotic chromosome movements, interacting with the KASH5-LINC complex.

This study shows that reduced glucose utilization in heart failure with preserved ejection fraction does not lead to increased fatty acid oxidation, even when glucose availability is limited.

This study shows metformin induces different mitochondrial remodeling in rat skeletal muscle based on baseline aerobic capacity and muscle type.