Coordinated subpocket engagement underlies nitazene potency at the μ-opioid receptor.
Margaret Jane Robinson, Li Chen, Abhishek Thakur, Kuo-Hao Lee, Lei Shi
The paper identifies structural determinants of nitazene potency at the μ-opioid receptor using functional assays, quantum mechanics, and molecular dynamics simulations.
ACS Chemical Neuroscience · Jul 5, 2026Peer-reviewedMolecular Biology