The paper identifies multiple allosteric sites on the D1 dopamine receptor that allow synergistic enhancement of GPCR signaling through combined positive allosteric modulators.

bioRxiv · Oct 21, 2025 · PreprintMolecular Biology

Dissociable control of motivation and reinforcement by distinct ventral striatal dopamine receptors

Juan Enríquez-Traba, Miguel A. Arenivar, Héctor E. Yarur, Chloe Noh, Rodolfo J. Flores, Tenley A. Weil, Snehashis Roy, Ted Björn Usdin, Christina T. LaGamma, Huikun Wang, Valerie S. Tsai, Damien Kerspern, Amy E. Moritz, David R. Sibley, Andrew Lutas, , Hugo A. Tejeda

This paper identifies distinct roles of dopamine D3 and D1 receptors in regulating motivation and reinforcement in the nucleus accumbens, showing compartmentalized signaling within the same cell type.

Nature Neuroscience · Dec 9, 2024Peer-reviewedNeuroscience

Chemogenetic ligands for translational neurotheranostics

Jordi Bonaventura, Mark A. G. Eldridge, Feng Hu, Juan L. Gomez, Marta Sánchez‐Soto, Ara M. Abramyan, Sherry Lam, Matthew A. Boehm, Christina M. Ruiz, Mitchell R. Farrell, Andrea Moreno, Islam Mustafa Galal Faress, Niels Andersen, John Y. Lin, Ruin Moaddel, , Michael Michaelides

The paper develops new DREADD agonists and a PET radiotracer for improved neuronal activity manipulation and noninvasive projection mapping in neurotheranostics.

bioRxiv · Dec 7, 2018 · PreprintNeuroscience