Author

Amy E. Moritz

National Institute of Neurological Disorders and Stroke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

David R. SibleyiD· 2 shared Abhishek Thakur· 1 shared Adele StewartiD· 1 shared Alexander Goldberg· 1 shared Andrew LutasiD· 1 shared Anthony W. Owens· 1 shared Ashley N. Nilson· 1 shared Bing XieiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersMolecular Biology

David R. SibleyORCID

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3 papers

Recent·Most cited

Multiple Allosteric Sites Allow for Synergistic Enhancement of GPCR Signaling

Kai Wang, Snezana T. Dimova, John N. Hanson, Abhishek Thakur, Youwei Xu, Y.-F. Liu, Amy E. Moritz, Alexander Goldberg, Bing Xie, Jayachandra Rayadurgam, Feijun Wang, Ashley N. Nilson, Kathryn D. Luderman, R. Benjamin Free, Wen Hu, , Youwen Zhuang

The paper identifies multiple allosteric sites on the D1 dopamine receptor that allow synergistic enhancement of GPCR signaling through combined positive allosteric modulators.

bioRxiv · Oct 21, 2025 · PreprintMolecular Biology

Kappa Opioid Receptor Antagonism Restores Phosphorylation, Trafficking and Behavior induced by a Disease Associated Dopamine Transporter Variant

Felix P. Mayer, Adele Stewart, Durairaj Ragu Varman, Amy E. Moritz, James D. Foster, Anthony W. Owens, Lorena Bianchine Areal, Raajaram Gowrishankar, Michelle Velez, Kyria Wickham, Hannah Phelps, Rania M. Katamish, Maximilian J. Rabil, Lankupalle Damodara Jayanthi, Roxanne A. Vaughan, , Sammanda Ramamoorthy

This study shows that KOR antagonism restores phosphorylation, trafficking, and behavior in a mouse model with a disease-associated DAT variant.

Molecular Psychiatry · May 29, 2025Peer-reviewedNeuroscience

Dissociable control of motivation and reinforcement by distinct ventral striatal dopamine receptors

Juan Enríquez-Traba, Miguel A. Arenivar, Héctor E. Yarur, Chloe Noh, Rodolfo J. Flores, Tenley A. Weil, Snehashis Roy, Ted Björn Usdin, Christina T. LaGamma, Huikun Wang, Valerie S. Tsai, Damien Kerspern, Amy E. Moritz, David R. Sibley, Andrew Lutas, , Hugo A. Tejeda

This paper identifies distinct roles of dopamine D3 and D1 receptors in regulating motivation and reinforcement in the nucleus accumbens, showing compartmentalized signaling within the same cell type.

Nature Neuroscience · Dec 9, 2024Peer-reviewedNeuroscience