WATER reveals heterochrony of molecular programs underlies developmental failure caused by minor spliceosome inhibition
Saren M. Springer, Abigail Boria, Kyle D. Drake, Kevon O. Afriyie, Kaitlin N. Girardini, Taveena Konakanchi, Isabella Stevens, Nicolás Camacho, Tomas Lopes, Rahul Kanadia
The paper introduces WATER, a method to analyze temporal gene expression, and shows that minor spliceosome inhibition disrupts developmental timing by redistributing molecular programs.
bioRxiv · May 13, 2026 · PreprintDevelopmental Biology