Author
University of Connecticut
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
4 papers
Recent·Most cited
Saren M. Springer, Abigail Boria, Kyle D. Drake…·Rahul Kanadia
The paper introduces WATER, a method to analyze temporal gene expression, and shows that minor spliceosome inhibition disrupts developmental timing by redistributing molecular programs.
Anke Augspach, Paola Francica, Kaitlin N. Girardini…·Mark A. Rubin
This study shows that targeting the minor spliceosome, specifically U6atac snRNA, disrupts DNA repair and overcomes therapy resistance in prostate and breast cancers.
Saren M. Springer, Katherine Fleck, Kaitlin N. Girardini…·Rahul Kanadia
The paper investigates how spatial organization and splicing of rare intron classes are related in human cells, finding that intron identity, not position, primarily determines splicing efficiency.
Kyle D. Drake, Saren M. Springer, Kevon O. Afriyie…·Rahul Kanadia
The paper shows that minor spliceosome inhibition in mouse forelimbs causes transcriptomic stalling and developmental delay, leading to micromelia while maintaining segmentation.