Kyle D. Drake

The paper introduces WATER, a method to analyze temporal gene expression, and shows that minor spliceosome inhibition disrupts developmental timing by redistributing molecular programs.

This study shows that RNA methylation, specifically m6A, regulates stress granule formation and function during erythropoiesis by modulating ATXN2 expression and RNA translation.

The paper identifies a BMP-dependent attractor state in melanoma precursor cells that precedes neural crest fate and is associated with ID1 expression in human melanoma.

This study identifies Ro5-3335 as a chemical that increases HSC clone number and clonal diversity by altering RUNX1 binding partners in zebrafish and mouse models.

The paper shows that minor spliceosome inhibition in mouse forelimbs causes transcriptomic stalling and developmental delay, leading to micromelia while maintaining segmentation.

This study shows that disrupting minor spliceosome function in mouse hypothalamic progenitors leads to altered neuronal subtype composition and obesity due to disrupted energy balance regulation.

The paper identifies MIG-encoded proteins as potential pan-viral drug targets, showing that repurposed anti-cancer drugs target these proteins.

This study shows that Trp53 ablation does not prevent microcephaly in Rnu11 cKO mice, but dKO mice show transcriptomic shifts and more severe cell cycle defects.

This study shows that disrupting the minor spliceosome, specifically by losing U11 snRNA, causes stunted limb growth without affecting limb patterning, due to increased minor intron retention and cell cycle delays.

The paper investigates the role of the minor spliceosome in cortical development by ablating Rnu11 in mice, revealing microcephaly due to radial glial cell death.