Saren M. Springer

WATER reveals heterochrony of molecular programs underlies developmental failure caused by minor spliceosome inhibition

The paper introduces WATER, a method to analyze temporal gene expression, and shows that minor spliceosome inhibition disrupts developmental timing by redistributing molecular programs.

Disentangling spatial organization and splicing of rare intron classes in the human genome

The paper investigates how spatial organization and splicing of rare intron classes are related in human cells, finding that intron identity, not position, primarily determines splicing efficiency.

Integrated multi-omics reveals minor spliceosome inhibition causes molecular stalling and developmental delay of the mouse forelimb.

The paper shows that minor spliceosome inhibition in mouse forelimbs causes transcriptomic stalling and developmental delay, leading to micromelia while maintaining segmentation.