Age-dependent topoisomerase I depletion alters recruitment of rDNA silencing complexes
Lindsey N. Power, Natalia Zawrotna, Manikarna Dinda, Abigail E. Weir, B. Bishal Paudel, Oshil Ghimire, Karolina Kisiel, Christopher T. Letai, Kevin A. Janes, Jeffrey S. Smith
The paper identifies topoisomerase I (Top1) depletion in aging yeast cells and shows its impact on rDNA silencing and replicative lifespan.
Journal of Biological Chemistry · Dec 17, 2025Peer-reviewedMolecular Biology