Author

Manikarna Dinda

University of VirginiaORCID 0000-0002-7222-2302Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:yeast· 3 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Research Focus:gene regulatory network inference· 2 Research Focus:spatial domain detection· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Jeffrey S. SmithiD· 3 shared Mingguang LiiD· 2 shared Ryan D. FineiD· 2 shared Shekhar SahaiD· 2 shared Abigail E. Weir· 1 shared Alexander L. KlibanoviD· 1 shared B. Bishal PaudeliD· 1 shared Benjamin Ate Kefas· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersMolecular Biology

Jeffrey S. SmithORCID

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4 papers

Recent·Most cited

Age-dependent topoisomerase I depletion alters recruitment of rDNA silencing complexes

Lindsey N. Power, Natalia Zawrotna, Manikarna Dinda, Abigail E. Weir, B. Bishal Paudel, Oshil Ghimire, Karolina Kisiel, Christopher T. Letai, Kevin A. Janes, Jeffrey S. Smith

The paper identifies topoisomerase I (Top1) depletion in aging yeast cells and shows its impact on rDNA silencing and replicative lifespan.

Journal of Biological Chemistry · Dec 17, 2025Peer-reviewedMolecular Biology

Discovery and therapeutic exploitation of Master Regulatory miRNAs in Glioblastoma

Shekhar Saha, Ying Zhang, Myron Keith Gibert, Collin Dube, Farina Hanif, Elizabeth Qian Xu Mulcahy, Sylwia Bednarek, Pawel Marcinkiewicz, Xiantao Wang, Gijung Kwak, Kadie Hudson, Yunan Sun, Manikarna Dinda, Tapas Saha, Fadila Guessous, , Roger Abounader

The paper identifies master regulatory miRNAs in glioblastoma and develops a therapeutic delivery method to inhibit tumor growth.

bioRxiv · Apr 1, 2025 · PreprintCancer Biology

Fob1-dependent condensin recruitment and loop extrusion on yeast chromosome III

Manikarna Dinda, Ryan D. Fine, Shekhar Saha, Zhenjia Wang, Chongzhi Zang, Mingguang Li, Jeffrey S. Smith

The paper identifies Fob1-dependent condensin recruitment and loop extrusion at the RDT1 locus on yeast chromosome III, linking it to MATa-specific organization during mating-type switching.

PLoS Genetics · Apr 14, 2023Peer-reviewedMolecular Biology

A Sir2-regulated locus control region in the recombination enhancer of Saccharomyces cerevisiae specifies chromosome III structure

Mingguang Li, Ryan D. Fine, Manikarna Dinda, Stefan Bekiranov, Jeffrey S. Smith

This paper identifies a Sir2-regulated locus control region in the recombination enhancer of yeast that controls chromosome III structure and mating-type switching.

PLoS Genetics · Aug 28, 2019Peer-reviewedMolecular Biology