ASS1 deficiency defines a therapeutic vulnerability in Philadelphia chromosome-positive acute lymphoblastic leukaemia
Michael James Austin, Shruti Patel, Ronas Taner Kesmez, Foteini Kalampalika, Claudia Davies, Amit Sud, Aytug Kizilors, Nicholas C. Lea, Paulo Inocêncio, Abigail Tappenden, Marianne Grantham, John S. Bomalaski, John G. Gribben, Miguel Ganuza, Peter Wojciech Szlosarek, Bela G. Patel
This study identifies ASS1 deficiency as a therapeutic target in Ph+ ALL, showing arginine deprivation induces apoptosis and overcomes TKI resistance.
bioRxiv · May 25, 2026 · PreprintCancer Biology