Author

Marianne Grantham

Barts Health NHS Trust

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:CUT&Tag· 1 Research Focus:differential expression· 1

Frequent Co-Authors

John G. GribbeniD· 2 shared Abigail Tappenden· 1 shared Alexis Nolin-LapalmeiD· 1 shared Alun Parsons· 1 shared Amit SudiD· 1 shared Ana Rio‐MachíniD· 1 shared Aytug Kizilors· 1 shared Bela G. PateliD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

John G. GribbenORCID

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2 papers

Recent·Most cited

ASS1 deficiency defines a therapeutic vulnerability in Philadelphia chromosome-positive acute lymphoblastic leukaemia

Michael James Austin, Shruti Patel, Ronas Taner Kesmez, Foteini Kalampalika, Claudia Davies, Amit Sud, Aytug Kizilors, Nicholas C. Lea, Paulo Inocêncio, Abigail Tappenden, Marianne Grantham, John S. Bomalaski, John G. Gribben, Miguel Ganuza, Peter Wojciech Szlosarek, Bela G. Patel

This study identifies ASS1 deficiency as a therapeutic target in Ph+ ALL, showing arginine deprivation induces apoptosis and overcomes TKI resistance.

bioRxiv · May 25, 2026 · PreprintCancer Biology

DEK::NUP214 acts as an XPO1-dependent transcriptional activator of essential leukemia genes

Fadimana Kaya, Findlay Bewicke‐Copley, Juho Jalmari Miettinen, Pedro Casado, Eve Leddy, Özgen Deniz, Vincent‐Philippe Lavallée, Céline Philippe, Jiexin Zheng, Florian Grebien, Naeem Khan, Szilvia Krizsán, Joseph J Saad, Alexis Nolin-Lapalme, Josée Hébert, , Ana Rio‐Machín

This study identifies DEK::NUP214 as an XPO1-dependent transcriptional activator of leukemia genes, showing selective response to XPO1 inhibitors in t(6;9) AML cases.

Leukemia · Apr 9, 2025Peer-reviewedCancer Biology