Double stranded RNA drives innate immune responses, sickness behavior and cognitive impairment dependent on dsRNA length, IFNAR1 expression and age
Niamh McGarry, Carol Murray, Sean Garvey, Abigail Wilkinson, Lucas Silva Tortorelli, Lucy Ryan, Lorna Hayden, Dáire Healy, Éadaoin W. Griffin, Edel Hennessy, Malathy Arumugam, Donal Skelly, Kevin J. Mitchell, Colm M. Cunningham
The paper investigates how dsRNA length, IFNAR1 expression, and age affect innate immune responses and cognitive impairment in mice using poly I:C.
Brain Behavior and Immunity · Apr 21, 2021Peer-reviewedNeuroscience