Lucas Silva Tortorelli

This study investigates the role of the locus coeruleus-mPFC circuit in attentional switching by using chemogenetic inhibition and calcium imaging in mice.

The paper identifies electrophysiological diversity in locus coeruleus neurons of mice, revealing fast-spiking interneurons whose activity is masked by anesthesia.

This study identifies distinct roles of prefrontal cortex neuron subtypes in cognitive flexibility during set shifting in mice.

The paper investigates how dsRNA length, IFNAR1 expression, and age affect innate immune responses and cognitive impairment in mice using poly I:C.

This study investigates how acute inflammation disrupts energy metabolism in mice and humans, linking it to behavioral and cognitive impairments like hypoactivity, delirium, and impaired cognition.

This study investigates how bidirectional pharmacological perturbations of the noradrenergic system affect tactile detection in mice, finding distinct behavioral impacts from localized versus systemic treatments.

This study shows that systemic inflammation causes acute cognitive dysfunction and brain injury through separate IL-1-dependent mechanisms, with implications for managing cognitive decline during illness.