Éadaoin W. Griffin

Double stranded RNA drives innate immune responses, sickness behavior and cognitive impairment dependent on dsRNA length, IFNAR1 expression and age

The paper investigates how dsRNA length, IFNAR1 expression, and age affect innate immune responses and cognitive impairment in mice using poly I:C.

Cholinergic signalling in the forebrain controls microglial phenotype and responses to systemic inflammation

This study shows that loss of basal forebrain cholinergic signaling leads to microglial activation and exaggerated inflammatory responses to systemic inflammation.

Acute inflammation alters energy metabolism in mice and humans: Role in sickness-induced hypoactivity, impaired cognition and delirium.

This study investigates how acute inflammation disrupts energy metabolism in mice and humans, linking it to behavioral and cognitive impairments like hypoactivity, delirium, and impaired cognition.

Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms

This study shows that systemic inflammation causes acute cognitive dysfunction and brain injury through separate IL-1-dependent mechanisms, with implications for managing cognitive decline during illness.