Edel Hennessy

This study shows that in the APP/PS1 AD mouse model, microglia and astrocytes are primed to produce exaggerated inflammatory responses to secondary stimuli, leading to cognitive impairments.

The paper investigates how dsRNA length, IFNAR1 expression, and age affect innate immune responses and cognitive impairment in mice using poly I:C.

This study shows that loss of basal forebrain cholinergic signaling leads to microglial activation and exaggerated inflammatory responses to systemic inflammation.

This study shows that systemic inflammation causes acute cognitive dysfunction and brain injury through separate IL-1-dependent mechanisms, with implications for managing cognitive decline during illness.