A Novel Therapeutic Approach using CXCR3 Blockade to Treat Immune Checkpoint Inhibitor-mediated Myocarditis
Yuhsin Vivian Huang, Daniel Lee, Yin Sun, Harrison Chou, Bruce Xu, Zachary Lin, Corynn Branche, Abraham Bayer, Sarah Waliany, Joel Neal, Heather Wakelee, Ronald Witteles, Patricia Nguyen, Edward Graves, Pilar Alcaide, , Han Zhu
This study identifies CXCR3-CXCL9/10 axis as a therapeutic target for ICI-mediated myocarditis using mouse models and human patient data.
bioRxiv · Jan 30, 2024 · PreprintCell Biology