Han Zhu

The paper describes the generation of an iPSC line from a patient with immune checkpoint inhibitor-induced myocarditis and type I diabetes, highlighting its pluripotency and potential for studying disease mechanisms.

The paper generates three iPSC lines from an ICIM patient and controls to study disease mechanisms and develop therapies.

This study investigates factors influencing HCM phenotype penetrance by comparing MYH7 mutations in isogenic hiPSC-CMs and shows that beta-adrenergic stimulation and gene dosage affect disease expression.

This study identifies CXCR3-CXCL9/10 axis as a therapeutic target for ICI-mediated myocarditis using mouse models and human patient data.

The paper investigates how mono- and bi-allelic ACTN2 mutations cause cardiomyopathy through distinct mechanisms using patient-derived iPSC-cardiomyocytes and CRISPR-Cas9 editing.