Author

Abraham Takkouche

University of California, Riverside

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:protein structure· 3 Organism:human· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Research Focus:phylogenetics / evolution· 1

Frequent Co-Authors

Adam GodzikiD· 3 shared Keita IchiiiD· 3 shared Lukasz Jaroszewski· 3 shared Alexander W. EnsmingeriD· 1 shared Alexei V. SavchenkoiD· 1 shared Cameron SemperiD· 1 shared Cathy LeiD· 1 shared Deepak T. PateliD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBioinformatics

Adam GodzikORCID

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Author profile →

3 papers

Recent·Most cited

Evolutionary history of ligand binding by the LRR domain of innate immunity receptors: the story of the TLR2 cavity

Rami Namou, Keita Ichii, Abraham Takkouche, Lukasz Jaroszewski, Adam Godzik

This study investigates the evolutionary history of the TLR2 cavity in vertebrates and invertebrates using AI protein structure predictions, showing its ancestral origin and convergent evolution in different species.

bioRxiv · Mar 30, 2026 · PreprintBioinformatics

Global atlas of predicted functional domains in Legionella pneumophila Dot/Icm translocated effectors

Deepak T. Patel, P. J. Stogios, Lukasz Jaroszewski, Malene L. Urbanus, Mayya Sedova, Cameron Semper, Cathy Le, Abraham Takkouche, Keita Ichii, Julie Innabi, Dhruvin Patel, Alexander W. Ensminger, Adam Godzik, Alexei V. Savchenko

The paper provides a global atlas of predicted functional domains in Legionella pneumophila effectors using 3D structure prediction, identifying novel domains and demonstrating their functional impact.

Molecular Systems Biology · Nov 19, 2024Peer-reviewedMicrobiology

Divergence of the Individual repeats in the leucine-rich repeat domains of human Toll-like receptors explain their diversity and functional adaptations.

Abraham Takkouche, Keita Ichii, Xinru Qiu, Lukasz Jaroszewski, Adam Godzik

This study shows how small variations in LRR repeats of human TLRs lead to structural and functional diversity, enabling recognition of different ligands and immune responses.

bioRxiv · Sep 30, 2024 · PreprintBioinformatics