Keita Ichii

This study investigates the evolutionary history of the TLR2 cavity in vertebrates and invertebrates using AI protein structure predictions, showing its ancestral origin and convergent evolution in different species.

The paper provides a global atlas of predicted functional domains in Legionella pneumophila effectors using 3D structure prediction, identifying novel domains and demonstrating their functional impact.

This study shows how small variations in LRR repeats of human TLRs lead to structural and functional diversity, enabling recognition of different ligands and immune responses.