Alexei V. Savchenko

Structural analysis of 23S rRNA methylating enzyme Cfr reveals RNA binding determinants for methylation regiospecificity and antibiotic resistance

This study determines the crystal structure of Cfr, identifies key residues for methylation specificity, and links these to antibiotic resistance in pathogens.

Global survey of secondary metabolism in Aspergillus niger via activation of specific transcription factors

The paper identifies novel secondary metabolites in Aspergillus niger by overexpressing transcription factors linked to cryptic biosynthetic gene clusters.

Structural and functional analyses of SARS-CoV-2 Nsp3 and its specific interactions with the 5' UTR of the viral genome

This study analyzes the structural and functional interactions of SARS-CoV-2 Nsp3 with the 5' UTR of the viral genome, identifying key domains involved in binding and translocation.

Structural architecture of TolQ-TolR inner membrane protein complex from opportunistic pathogen Acinetobacter baumannii

The paper presents cryo-EM structures of the TolQ-TolR complex from Acinetobacter baumannii, revealing structural changes related to PMF energy transfer and cell envelope organization.

Torsional Twist of the SARS-CoV and SARS-CoV-2 SUD-N and SUD-M domains

The paper resolves the x-ray structure of SARS-CoV and SARS-CoV-2 SUD-N/M domains and shows they have rotational flexibility, with disulfide bonds absent in pangolin-SARS and related viruses.

Cryo-EM Structure of Salmonella typhimurium ArnC; the Key Enzyme in Lipid-A Modification Conferring Polymyxin Resistance

The paper reports cryo-EM structures of Salmonella typhimurium ArnC in apo and UDP-bound forms, revealing its tetrameric structure and conformational changes upon UDP binding.

Global atlas of predicted functional domains in Legionella pneumophila Dot/Icm translocated effectors

The paper provides a global atlas of predicted functional domains in Legionella pneumophila effectors using 3D structure prediction, identifying novel domains and demonstrating their functional impact.

Functional and Structural Characterization of an IclR Family Transcription Factor for the Development of Dicarboxylic Acid Biosensors

This paper characterizes the PcaR transcription factor, solving its crystal structures and demonstrating its function as a dicarboxylic acid biosensor in yeast.