P. J. Stogios

This study determines the crystal structure of Cfr, identifies key residues for methylation specificity, and links these to antibiotic resistance in pathogens.

The paper identifies structure-activity relationships for diarylpyrazole inhibitors of the fungal kinase Yck2, showing improved selectivity and antifungal activity.

This study analyzes the structural and functional interactions of SARS-CoV-2 Nsp3 with the 5' UTR of the viral genome, identifying key domains involved in binding and translocation.

The paper resolves the x-ray structure of SARS-CoV and SARS-CoV-2 SUD-N/M domains and shows they have rotational flexibility, with disulfide bonds absent in pangolin-SARS and related viruses.

The paper provides a global atlas of predicted functional domains in Legionella pneumophila effectors using 3D structure prediction, identifying novel domains and demonstrating their functional impact.

The paper presents a yeast-based method to identify informative missense mutations in bacterial effector proteins and validates it using three effectors from Legionella pneumophila.

This paper characterizes the PcaR transcription factor, solving its crystal structures and demonstrating its function as a dicarboxylic acid biosensor in yeast.