Synuclein alpha accumulation mediates podocyte injury in Fabry nephropathy
Ahmed Abed, Fabian Braun, Dominik Sellung, Mathias Woidy, Øystein Eikrem, Nicola Wanner, Katharina von Cossel, Nicole Muschol, Søren W. Gersting, AC Muntau, Oliver Kretz, Behzad Najafian, Camilla Tøndel, Michael S. Mauer, T Bork, , TB Huber
This study identifies alpha-synuclein accumulation as a mediator of podocyte injury in Fabry disease, showing that targeting SNCA improves lysosomal function beyond enzyme replacement therapy.
bioRxiv · Dec 17, 2021 · PreprintMolecular Biology