Mice lacking the endocannabinoid-synthesizing enzyme NAPE-PLD exhibit sex-dependent dysregulations in responsiveness to oxycodone and a natural reward
Taylor J. Woodward, Emily Fender Sizemore, Ananya Balaji, Ada Port, John Hainline, Hasaan A Kazi, Serge H. Luquet, Ken Mackie, Andrea G. Hohmann
This study investigates the role of NAPE-PLD in opioid responsiveness and finds sex-dependent differences in oxycodone and sucrose consumption in knockout mice.
Neuropharmacology · Nov 1, 2025Peer-reviewedNeuroscience