Acetaminophen alters endogenous lipid signaling and attenuates pathological pain through a mechanism requiring diacylglycerol lipase, monoacylglycerol lipase and cannabinoid CB1 receptors in mice
Carlos Henrique Alves Jesus, Jonah L. Wirt, Taylor J. Woodward, Luana Assis Ferreira, Wenwen Du, John Hainline, Mirjam C. W. Huizenga, Lara Rems, Alexandros Makriyannis, Jenna A. Himelstein, Noah M. Brauer, Mario van der Stelt, Heather B. Bradshaw, Andrea G. Hohmann
This study shows acetaminophen reduces pain by altering lipid signaling via cannabinoid receptors and enzymes in mice.
Neuropharmacology · Sep 7, 2026Peer-reviewedNeuroscience