Oncogene SETDB1s Dual Role in Endometrial Cancer: Driving Tumor Progression and Immune Escape
Kiarash Salari, Jiaqing Hao, Ryan Jilek, Matthew Wells, Tianyue Li, Eleanor Johnson, Wendy Meng, Ethan Zibble, Adam Allen, Jack A. Gilbert, Ryan Mclerran, Emma Schuett, Claudia R. Oliva, Corinne E. Griguer, David Kyle Meyerholz, , Shujie Yang
This study identifies SETDB1's dual role in endometrial cancer by promoting tumor growth and enabling immune evasion through gene regulation and macrophage suppression.
bioRxiv · Apr 23, 2025 · PreprintCancer Biology