Henry L. Keen

The paper compares MEK inhibitor effects on iPSC-derived RPE cells from patients with and without MEKAR, finding differential gene expression and phagocytic activity.

The paper identifies differentially methylated CpG sites in twins discordant for NSCL/P, linking them to retinoic acid signaling and chromatin regulation.

This study uses spatial transcriptomics to show that MANF deficiency in Purkinje cells increases ER stress and vulnerability to alcohol-induced neurodegeneration in a sex-dependent manner in mice.

This study identifies SETDB1's dual role in endometrial cancer by promoting tumor growth and enabling immune evasion through gene regulation and macrophage suppression.

This study shows that FABP4 in tumor-associated macrophages promotes breast cancer metastasis by mediating lipid accumulation and lipolysis in response to unsaturated fatty acids.