David Kyle Meyerholz

This paper describes a trimeric inhibitor, S22, that stabilizes the SARS-CoV-2 spike protein in a closed conformation, preventing ACE2 binding and viral entry.

This study shows that the heme receptor ChuA is essential for Campylobacter jejuni to efficiently colonize the colon and cause inflammation.

This study identifies raffinose as a dietary fiber that promotes bifidobacterial persistence in the gut during weaning, with implications for host health and inflammation.

This study shows that intratumoral plasma cells are essential for CD8+ T cell activation and response to immune checkpoint blockade therapy in MPNSTs.

This study defines a functional correction threshold for gene therapies in PCD by analyzing how mixed populations of mutant and wild-type ciliated cells affect mucociliary transport.

This paper shows that in utero ivacaftor treatment rescues multiple organ defects in CFTR-G551D pigs, improving pancreatic, gallbladder, and vas deferens function.

This study shows IL-13 protects airway epithelial cells from SARS-CoV-2 infection in vitro but worsens disease severity in mice through eicosanoid signaling.

This study identifies SETDB1's dual role in endometrial cancer by promoting tumor growth and enabling immune evasion through gene regulation and macrophage suppression.

This study investigates how Ebola virus infects and accumulates in skin tissues of infected animals, identifying TIM-1 as a critical host receptor for viral dissemination.

This study shows that the alpha 1-adrenergic antagonist terazosin enhances glycolysis and is neuroprotective in Alzheimer's disease by reducing amyloid pathology and slowing cognitive decline.

This study identifies pulmonary complement activation in a mouse model of severe COVID-19, showing local complement production and its role in lung injury.

This paper develops a PCD pig model with DNAI1 mutations and characterizes its respiratory and sinus disease features, showing similarities to human PCD.

The paper develops the first turtle-derived hepatic organoids from multiple species, enabling in vitro studies of unique adaptations and biomedical applications.

A selective androgen receptor modulator microparticle formulation alleviates widespread muscle pain in male and female mice while being non-toxic.

This study examines interval timing deficits in P301S tau transgenic mice, finding they consistently underestimate temporal intervals compared to wild-type controls.

The paper compares gene expression and function of airway cell types in small and large porcine airways, finding distinct transcriptomes and functional roles.

The paper validates CNS-related antibodies in a miniswine model of neurofibromatosis type 1 to support translational research.

This study characterizes pain and sleep behaviors in a porcine model of NF1, identifying sex-dependent differences and potential therapeutic targets.