Intact learning and memory in mice incapable of de novo myelination
Matthew Swire, Stuart G. Nayar, Yi Jiang, Adam Halko, Marcus Lloyd, Katsutoshi Ogasawara, Koujiro Tohyama, Thomas Philips, Jeffrey D. Rothstein, Huiliang Li, William David Richardson
This study shows that motor and fear learning in mice do not require newly formed myelin sheaths or rapid saltatory conduction, as Mbp-cKO mice with impaired myelination still learned and remembered normally.
bioRxiv · Jun 16, 2026 · PreprintNeuroscience