Huiliang Li

Intact learning and memory in mice incapable of de novo myelination

This study shows that motor and fear learning in mice do not require newly formed myelin sheaths or rapid saltatory conduction, as Mbp-cKO mice with impaired myelination still learned and remembered normally.

A Paracrine-to-Autocrine Shunt of GREM1 Fuels Colorectal Cancer Metastasis via ACVR1C

This study identifies a paracrine-to-autocrine GREM1 signaling shunt in colorectal cancer that promotes metastasis via ACVR1C, highlighting a mechanism of signaling autonomy in advanced stages.

The INO80 chromatin remodeling complex regulates histone H2A.Z mobility and the G1-S transition in oligodendrocyte precursors

Adult oligodendrogenesis gates arcuate neuronal glucose sensing through remodelling of the blood-hypothalamus barrier via ADAMTS4

This study shows that adult oligodendrogenesis in the median eminence regulates glucose homeostasis through ADAMTS4 expression, impacting the blood-hypothalamus barrier and neuronal glucose sensing in the arcuate nucleus.

GPR158 in pyramidal neurons mediates social novelty behavior via modulating synaptic transmission in mice

This study shows that GPR158 in pyramidal neurons affects social novelty behavior in mice by modulating synaptic transmission and glutamate vesicle density in the medial prefrontal cortex.

Oligodendrocyte dynamics dictate individual performance outcomes of working memory training in mice

The paper shows that oligodendrocyte production is crucial for improving working memory performance in mice during maze training.