William David Richardson

This study shows that motor and fear learning in mice do not require newly formed myelin sheaths or rapid saltatory conduction, as Mbp-cKO mice with impaired myelination still learned and remembered normally.

This study shows that adult oligodendrogenesis in the median eminence regulates glucose homeostasis through ADAMTS4 expression, impacting the blood-hypothalamus barrier and neuronal glucose sensing in the arcuate nucleus.

This study shows that ablating adult oligodendrogenesis alters brain microstructure and activity without affecting behaviour.

This study shows that myelin in the adult mouse median eminence continuously turns over, regulated by nutritional status and microglia.

This paper develops a pharmacogenetic model to ablate oligodendrocyte progenitor cells (OPCs) in adult mice, achieving 98.6% depletion and revealing compensatory mechanisms from V-SVZ-derived NPCs.

The paper shows that oligodendrocyte production is crucial for improving working memory performance in mice during maze training.