Disrupted RGS coupling underlies a clinically distinct subset of GNAO1-related disorder
Elizabeth G. Obarow, Erika Takle Axeen, Cornelius F. Boerkoel, Joseph Gordon, Larissa Heideman, Hyun Lee, Laura A. van de Pol, Ashley Rice, Yibo Si, H. Dalton Taylor, Adam Tengolics, Chloe E. Viviers, Paul A. Slesinger, Henrik Gunnar Dohlman
The paper identifies a subset of GNAO1 mutations that disrupt RGS coupling, leading to milder clinical symptoms in patients.
bioRxiv · Oct 29, 2026 · PreprintBiochemistry