Paul A. Slesinger

Disrupted RGS coupling underlies a clinically distinct subset of GNAO1-related disorder

The paper identifies a subset of GNAO1 mutations that disrupt RGS coupling, leading to milder clinical symptoms in patients.

Identification of alcohol use disorder-associated and ethanol-responsive proteins and candidate biomarkers using human cortical organoids

This study identifies AUD-associated and ethanol-responsive proteins in human cortical organoids and finds candidate biomarkers linked to AUD and ethanol exposure.

PHOTORELEASE OF OXYTOCIN IN VIVO USING PHOTOSWITCHABLE NANOVESICLES MODULATES HIPPOCAMPAL CIRCUIT DYNAMICS AND SOCIAL BEHAVIOR

This study develops photoswitchable nanovesicles for controlled in vivo neuropeptide delivery, showing they modulate hippocampal circuit dynamics and social behavior in mice.

SELECTIVE ACTIVATION OF GIRK POTASSIUM CHANNELS REDUCES BEHAVIORAL AND BRAIN RESPONSES TO ETHANOL IN MICE

This study shows that activating GIRK channels with GiGA1 reduces ethanol reward and intake in mice, suggesting it as a potential treatment for AUD.

ZBTB7A regulates MDD-specific chromatin signatures and astrocyte-mediated stress vulnerability in orbitofrontal cortex

The paper identifies ZBTB7A as a key regulator of MDD-specific chromatin signatures and astrocyte-mediated stress vulnerability in the orbitofrontal cortex.

Phenotypic complexities of rare heterozygous neurexin-1 deletions

This study investigates the phenotypic complexities of rare heterozygous NRXN1 deletions, showing cell-type-specific synaptic effects through LOF and GOF mechanisms, highlighting the need for precision medicine strategies.

High-throughput measurements of neuronal activity in single human iPSC-derived glutamate neurons

This paper develops a high-throughput method to measure neuronal activity in human iPSC-derived glutamatergic neurons using Mg2+-free ACSF and confirms donor-specific firing patterns.

Key residue Unlocks Dual PIP2-Dependent and Independent Gating in G Protein-Gated Inwardly Rectifying Potassium Channels

The paper identifies R92 as a key residue in GIRK2 channels that modulates both PIP2-dependent and independent gating mechanisms through experimental and structural analyses.

Polygenic Risk for Alcohol Use Disorder Affects Cellular Responses to Ethanol Exposure in a Human Microglial Cell Model

This study examines how polygenic risk scores for Alcohol Use Disorder affect microglial responses to ethanol exposure in human iPSC-derived microglia.

Integrated Single-Cell Multiomic Profiling of Caudate Nucleus Suggests Key Mechanisms in Alcohol Use Disorder

The paper uses multiomic profiling of the caudate nucleus to identify gene expression and chromatin changes in AUD, linking them to risk genes through QTL analysis.

Simultaneous dual-color calcium imaging in freely-behaving mice

This paper introduces a dual-channel miniscope for simultaneous two-wavelength calcium imaging in freely behaving mice, showing spatial coding changes over time.

Upregulated GIRK2 counteracts ethanol-induced changes in excitability and respiration in human neurons

The paper investigates how upregulated GIRK2 affects ethanol-induced changes in human neurons, showing it counteracts excitability and respiration changes.

Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons

This study shows that KCNJ6 noncoding variants increase excitability in human glutamatergic neurons, an effect reversed by ethanol exposure.

Probing neuropeptide volume transmission in vivo by a novel all-optical approach

The paper develops an all-optical method to study neuropeptide volume transmission in mouse neocortex, finding faster SST transmission in a chemically degraded extracellular matrix.

Induction of Dopaminergic Neurons for Neuronal Subtype-Specific Modeling of Psychiatric Disease Risk

This study develops a method to efficiently generate dopaminergic neurons from hiPSCs and shows they model psychiatric disease risk genes.

Multi-omics integration analysis identifies novel genes for alcoholism with potential link to neurodegenerative diseases

The paper integrates GWAS data with multi-omics datasets to identify novel genes for alcohol use disorder and link them to neurodegenerative diseases.

Structural basis of GIRK2 channel modulation by cholesterol and PIP2

The paper presents cryoEM structures of GIRK2 with and without cholesterol analog and PIP2, revealing how CHS modulates channel function by interacting with PIP2 in the transmembrane domain.

Molecular Networks and Key Regulators of the Dysregulated Neuronal System in Alzheimer’s Disease

This study identifies molecular networks and key regulators in Alzheimer’s Disease using integrative genomics and experimental validation.

An Efficient Platform For Astrocyte Differentiation From Human Induced Pluripotent Stem Cells

The paper describes a method to generate highly pure astrocytes from hiPSCs, showing they resemble primary astrocytes and have functional properties relevant to neurological disorders.