Henrik Gunnar Dohlman

The paper identifies a subset of GNAO1 mutations that disrupt RGS coupling, leading to milder clinical symptoms in patients.

This study classifies GNAO1 mutations into functional categories and evaluates therapeutic strategies for NEDIM and DEE, finding that specific mutations are linked to hyperkinetic symptoms and that small molecules reduce hyperlocomotion.

The paper identifies subtype-specific conserved residues in G protein subtypes that modulate Gβγ coupling, showing conservation does not guarantee functional equivalence.

The paper examines non-redundant roles of paralogous proteins in yeast glucose-sensing pathways through gene deletion and multi-omics analyses.

The paper identifies sequence motifs conserved in paralogous proteins despite functional divergence in post-translational modification.

This study compares two glucose receptor systems in yeast, showing they regulate distinct metabolic processes and signaling pathways.

This paper investigates the roles of G protein subunits Gpa2 and Asc1/RACK1 in glucose signaling using transcriptomics and metabolomics in yeast, finding distinct contributions to sugar and amino acid metabolism.

The paper develops a predictive model of gene expression in yeast to understand how regulatory motifs coordinate the mating response to dynamic and persistent stimuli.

The paper uses mathematical models to identify positive feedback regulation between Hog1 and its phosphatases in yeast osmotic stress response.