Evolution of temperature dependence of TRPM2 channel gating and inactivation in vertebrates
Ádám Bartók, Adam V. Toth, László Csanády
This study compares temperature sensitivity of TRPM2 channels in zebrafish and human, finding that human TRPM2 gating evolved to be temperature dependent while inactivation was already temperature sensitive in early vertebrates.
Journal of Molecular Biology · Oct 24, 2025Peer-reviewedBiophysics