László Csanády

Evolution of temperature dependence of TRPM2 channel gating and inactivation in vertebrates

This study compares temperature sensitivity of TRPM2 channels in zebrafish and human, finding that human TRPM2 gating evolved to be temperature dependent while inactivation was already temperature sensitive in early vertebrates.

Structural determinants of protein kinase A essential for CFTR channel activation

This paper identifies structural determinants of PKA-C essential for CFTR activation, showing two distinct regions mediate reversible and irreversible activation, and highlights the role of PKA-C myristoylation in this process.

The structures of protein kinase A in complex with CFTR: mechanisms of phosphorylation and reversible activation

This study presents cryo-EM structures of PKA-C bound to CFTR, revealing mechanisms of phosphorylation and reversible activation through catalytic interactions and conformational flexibility.