Cell cycle-gated feedback control mediates desensitization to interferon stimulation
Anusorn Mudla, Yanfei Jiang, Kei‐ichiro Arimoto, Bingxian Xu, Adarsh Rajesh, Andy P Ryan, Wei Wang, Matthew D. Daugherty, Dong‐Er Zhang, Nan Hao
The paper investigates how type I interferon signaling in human epithelial cells processes repetitive stimulation through cell cycle-gated feedback control, revealing duration-dependent desensitization.
eLife · Sep 18, 2020Peer-reviewedSystems Biology