Nan Hao

The paper develops a framework using evolved microbial diversity and machine learning to enable combinatoric biosensing of multiple analytes in complex environments.

The paper identifies yeast-derived lipids that extend lifespan in Drosophila by remodeling metabolism in the gut and brain, enhancing tissue homeostasis and communication.

This study uses MD simulations and FLIM-FRET to show Dsup binds DNA in living cells and enhances cell survival under oxidative stress in mammalian and yeast cells.

BudFinder uses a masked auto-encoder to detect yeast cell divisions with minimal training data, reducing manual labeling by over five-fold while maintaining accuracy.

This paper shows that manipulating intracellular ATP levels in yeast through synthetic ATP import extends cellular lifespan and reveals distinct metabolic pathways involved in aging.

This study analyzes two aging modes in yeast, showing spherical budding cells better control growth and size, and develops a model to test mechanisms of bud morphogenesis during aging.

This study develops a mathematical model to analyze how environmental glucose fluctuations influence yeast aging and identifies strategies to enhance cellular longevity.

The paper investigates how telomerase promoter mutations affect melanoma cell morphology using isogenic cell lines and dual-color reporters, finding C250T mutations cause more pronounced morphological changes.

This study investigates how dynamic interferon-gamma stimulation affects pro-inflammatory gene expression in macrophages, revealing gene-specific response patterns and stochasticity in CXCL10 expression.

The paper investigates how type I interferon signaling in human epithelial cells processes repetitive stimulation through cell cycle-gated feedback control, revealing duration-dependent desensitization.

The paper shows that interactions between chromatin silencing and mitochondrial pathways create an epigenetic landscape that determines cell fate during aging, and introduces a genetically engineered long-lived state.

The paper investigates how yeast cells encode short- and long-lived memory of stress adaptation through PKA-regulated networks and trehalose metabolism.

The paper tracks replicative aging in yeast cells and finds that intermittent heterochromatin silencing loss regulates lifespan, with Sir2 deacetylase playing a key role.