Fluid shear magnitude, mechanical history and actin-sensitive coupling shape Piezo1 signalling
See Swee Tang, Margaret Gheorghita, Benjamin Hansen, Jennifer Frattolin, Konstantinos Kalyviotis, Adele Jing Ying Lam, Simon Tupin, Luana A. Osório, Julian Boecker, Joseph M. Sherwood, James E. Moore, Victoria Salem, Periklis Pantazis
This study shows that Piezo1 signaling is influenced by force magnitude, mechanical history, and actin coupling under fluid shear, using a genetically encoded reporter in engineered cells.
bioRxiv · Oct 12, 2026 · PreprintBiophysics