Joseph M. Sherwood

Engineered microvessel networks -- Longitudinal transcriptomic profiling validates chip-grown tissues as a robust model for studying vasculature

The paper validates chip-grown vascular tissues as a model for studying vasculature by showing cell provenance affects network formation and transcriptomic profiles.

Fluid shear magnitude, mechanical history and actin-sensitive coupling shape Piezo1 signalling

This study shows that Piezo1 signaling is influenced by force magnitude, mechanical history, and actin coupling under fluid shear, using a genetically encoded reporter in engineered cells.

Organ on chip model of respiratory vascular interactions under COPD relevant oxidative stress

This study develops an organ-on-chip model to investigate respiratory-vascular interactions under oxidative stress, revealing how airway injury drives vascular inflammation and remodeling in COPD.

Corticosteroids elevate intraocular pressure through suppression of TREK-1 signaling

This study shows corticosteroids increase intraocular pressure by suppressing TREK-1 channels in trabecular meshwork cells, leading to ocular hypertension, which can be counteracted by TREK-1 agonists.

A Microfluidic Blood Vessel-On-Chip Model of Thrombosis

This paper develops a thrombus-on-chip model with endothelium and whole blood to study thrombosis, showing TNF-activation increases platelet adhesion and fibrin deposition.