Synergistic RAS-MAPK and AKT Activation in MYC-Driven Tumors via Adjacent PVT1 Rearrangements
Ashutosh Tiwari, Utkarsha Paithane, Jordan Friedlein, Kojiro Tashiro, Olivier Saulnier, Karina Barbosa, Quang M. Trinh, Bryan Hall, Shrawantee Saha, Aditi Soni, Takuma Nakashima, Andrey A. Bobkov, Lynn Miya Fujimoto, Rabi Murad, Svetlana Rajkumar Maurya, , Anindya Bagchi
This paper identifies how PVT1 rearrangements in MYC+ cancers generate oncogenic peptides that synergistically activate MYC, AKT, and RAS-MAPK pathways, enhancing tumor aggressiveness.
bioRxiv · Feb 17, 2025 · PreprintCancer Biology