Author

Brian P. James

Sanford Burnham Prebys Medical Discovery InstituteORCID 0000-0002-7411-9608Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Rabi MuradiD· 2 shared Aditi Soni· 1 shared Alexandre Rosa CamposiD· 1 shared Ana Dominguez Andres· 1 shared Andrey A. BobkoviD· 1 shared Anindya BagchiiD· 1 shared Aniruddha Deshpande· 1 shared Aniruddha J. DeshpandeiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Rabi MuradORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintFeb 17, 2025

Synergistic RAS-MAPK and AKT Activation in MYC-Driven Tumors via Adjacent PVT1 Rearrangements

Ashutosh Tiwari, Utkarsha Paithane, Jordan Friedlein…·Anindya Bagchi

This paper identifies how PVT1 rearrangements in MYC+ cancers generate oncogenic peptides that synergistically activate MYC, AKT, and RAS-MAPK pathways, enhancing tumor aggressiveness.

1 citation

humanDNA methylation

BioinformaticsbioRxivPreprintAug 18, 2020

SARS-CoV-2 ORF9c Is a Membrane-Associated Protein that Suppresses Antiviral Responses in Cells

Ana Dominguez Andres, Yongmei Feng, Alexandre Rosa Campos…·Ze’ev A. Ronai

The 73-amino-acid SARS-CoV-2 membrane-associated protein ORF9c suppresses interferon, antigen presentation, and complement pathways while inducing IL-6 signaling in lung epithelial cells, an effect blunted by proteasome or VCP inhibition.

66 citations

humanproteomics